Olanzapine reduces mania more effectively than divalproex, but has more adverse effects

Olanzapine reduces mania more effectively than divalproex, but has more adverse effects.

Participants 248 adults hospitalised with acute bipolar manic or mixed episodes, with or without psychotic features (confirmed with Structured Clinical Interview for DSM-IV and minimum score of 20 on the Young Mania Rating Scale at both screening and randomisation); mean age 41 years (range 18–75); 57% women. Exclusion criteria were unstable or serious medical illness; DSM-IV drug or alcohol de...

10 mg intramuscular olanzapine reduces acute agitation in schizophrenia more effectively than lower doses.

Olanzapine versus divalproex in the treatment of acute mania.

OBJECTIVE The effects of olanzapine and divalproex for the treatment of mania were compared in a large randomized clinical trial. METHOD A 3-week, randomized, double-blind trial compared flexibly dosed olanzapine (5-20 mg/day) to divalproex (500-2500 mg/day in divided doses) for the treatment of patients hospitalized for acute bipolar manic or mixed episodes. The Young Mania Rating Scale and ...

Olanzapine was more effective than lorazepam at 2 hours but not at 24 hours in bipolar mania with acute agitation.

Patients 201 patients >18 years of age (mean age 40 y, 53% men) who had bipolar disorder, mania, or a mixed diagnosis confirmed with the Structured Clinical Interview for DSMIII-R considered by the site physician to have severe agitation requiring injections and who had a total score >14 on the 5 item Positive and Negative Syndrome Scale-Excited Component (PANSS-EC) scale with >1 individual sco...

Review: clonidine is more effective than placebo for long-term smoking cessation, but has side effects.

MAIN RESULTS 6 trials (n=776) met the inclusion criteria. Assessment of blinding and details of the randomisation procedure were not reported in any of the studies. 4 of the 6 trials used biochemical verification of smoking abstinence using plasma cotinine (,15 m/ml), salivary cotinine (,20 m/ml), expired carbon monoxide (,10 ppm), or random plasma thiocyanate monitoring. Volunteer participants...